Immune disease is a condition resulting from a conflict between antigens and antibodies. An autoimmune disease occurs when the immune system attacks selfmolecules as a result of a breakdown of immunologic tolerance to autoreactive immune cells . It is admitted today that unexplained infertility is often associated to immunologic factors . This condition may be a result of autoimmunity (in man and woman) or of isoimmunity (in woman).
 

Immunological Fertility Testing
 

People with the following indications may want to consider getting tested by a Reproductive Immunologist. A Reproductive Immunologist differs from a Reproductive Endocrinologist, which most couples are referred to when fertility issues are not determined by an OB&GYN, or other doctor. Reproductive Immunologists have the training and skills to determine if there is in fact an immunological response gone awry that is causing difficulty in getting pregnant or carrying to full term.
 

2 or more miscarriages after the age of 35

2 IVF failures after the age of 35

3 miscarriages before the age of 35

1 failed IVF before the age of 35

Poor egg production from a stimulated cycle (6 eggs or less)

Blighted ovum

Pre-existing immune problems (Lupus, Rheumatoid Arthritis, MS)

Unexplained Infertility diagnosis

Previous pregnancies showing retarded fetal growth

1 healthy pregnancy with all subsequent pregnancies ending in miscarriage

Endometriosis, especially stage 1 & 2

Cold and flu-like symptoms, sore throat noted regularly after ovulation, IUI, or IVF transfer

Family history of immune disorders, either side of the family.